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Recommendation
Systemic therapy planning considerations – Premenopausal women
Offer temporary ovarian suppression with a gonadotrophin releasing hormone (GnRH) agonist such as goserelin during chemotherapy to all premenopausal breast cancer patients undergoing chemotherapy who are interested in preventing early menopause and/or preserving fertility. Commence goserelin at least one week prior to the commencement of chemotherapy.
Temporary ovarian suppression with LHRHa during chemotherapy should be recommended to all pre-menopausal breast cancer patients undergoing chemotherapy who are interested in ovarian function and/or fertility preservation
The desirable effects of an intervention clearly outweigh the undesirable effects (the intervention is to be put into practice), or the undesirable effects of an intervention clearly outweigh the desirable effects (the intervention is not to be put into practice)
How this guidance was developed
This recommendation was adopted from the AIOM 2017 guidelines (Italy). The source recommendation was based on a systematic review of the evidence conducted to January 2016 and was graded ‘strong’ (using GRADE methods) by the source guideline authors. The source recommendation was accepted with minor stylistic changes, but with no changes to the meaning or tone.
Related guidance by topic
Systemic therapy planning considerations – Premenopausal women
Recommendation
Offer temporary ovarian suppression with a gonadotrophin releasing hormone (GnRH) agonist such as goserelin during chemotherapy to all premenopausal breast cancer patients undergoing chemotherapy who are interested in preventing early menopause and/or preserving fertility. Commence goserelin at least one week prior to the commencement of chemotherapy.
Principles in action
Patient-centred care
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Safe and quality care
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Supportive care
This recommendation was adopted from the AIOM 2017 guidelines (Italy). The source recommendation was based on a systematic review of the evidence conducted to January 2016 and was graded ‘strong’ (using GRADE methods) by the source guideline authors. The source recommendation was accepted with minor stylistic changes, but with no changes to the meaning or tone.
Related guidance by topic
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Reproductive and sexual health
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