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Practice Point
Adjuvant chemotherapy – Combination with endocrine therapy
Chemotherapy can be given concurrently with the gonadotropin-releasing hormone (GnRH) agonist goserelin but not with tamoxifen.
How this guidance was developed
No evidence-based source recommendation was identified for this topic, which was considered an important aspect of care. This practice point was developed using an expert consensus process, with reference to findings from two RCTs: the POEMS clinical trial (goserelin for ovarian protection during breast cancer adjuvant chemotherapy) and the SOFT and TEXT clinical trials (tailoring adjuvant endocrine therapy for premenopausal breast cancer).
Related guidance by topic
Adjuvant chemotherapy – Combination with endocrine therapy
Practice Point
Chemotherapy can be given concurrently with the gonadotropin-releasing hormone (GnRH) agonist goserelin but not with tamoxifen.
Principles in action
Safe and quality care
No evidence-based source recommendation was identified for this topic, which was considered an important aspect of care. This practice point was developed using an expert consensus process, with reference to findings from two RCTs: the POEMS clinical trial (goserelin for ovarian protection during breast cancer adjuvant chemotherapy) and the SOFT and TEXT clinical trials (tailoring adjuvant endocrine therapy for premenopausal breast cancer).
Related guidance by topic
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Reproductive and sexual health
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