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Recommendation
Anthracyclines and taxanes – Dosage
The cumulative dose of anthracycline in a two-drug regimen should not exceed 240 mg/m2 for doxorubicin, or 720 mg/m2 for epirubicin.
For patients with high-risk disease who will not receive a taxane, an optimal-dose anthracycline three-drug regimen (cumulative dose of doxorubicin ≥ 240mg/m2 or epirubicin ≥ 600mg/m2 but no higher than 720 mg/m2) that contains cyclophosphamide is recommended. The cumulative dose of doxorubicin in two-drug regimens should not exceed 240 mg/m2
How this guidance was developed
This recommendation was adapted from the ASCO 2016 guidelines (US). The source recommendation was based on a systematic review of the evidence conducted to July 2015 and was not graded by the source guideline authors. The source recommendation was simplified by removing the detail and the specification of the patient population.
Anthracyclines and taxanes – Dosage
Recommendation
The cumulative dose of anthracycline in a two-drug regimen should not exceed 240 mg/m2 for doxorubicin, or 720 mg/m2 for epirubicin.
Principles in action
Safe and quality care
This recommendation was adapted from the ASCO 2016 guidelines (US). The source recommendation was based on a systematic review of the evidence conducted to July 2015 and was not graded by the source guideline authors. The source recommendation was simplified by removing the detail and the specification of the patient population.