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Recommendation
Adjuvant endocrine therapy – Indications #2
Consider adjuvant endocrine therapy in patients with ER-negative but PR-positive tumours, noting that this scenario is extremely unusual, and consideration should be given to repeat confirmatory testing.
Consensus was not reached on whether to administer adjuvant endocrine therapy in patients with ER- but PR+ tumours
How this guidance was developed
This recommendation was adapted from the CCO 2014 guidelines on systemic therapy (Canada). The source recommendation was based on a systematic review of the evidence conducted to March 2012 and was not graded by the source guideline authors. The source recommendation was adapted by making it more directive, replacing 'consensus was not reached' with 'consider' but noting that tumours of this type are rare. The repeat confirmatory testing can be repeat ER testing or repeat ER and PR testing on a different block if available.
Adjuvant endocrine therapy – Indications #2
Recommendation
Consider adjuvant endocrine therapy in patients with ER-negative but PR-positive tumours, noting that this scenario is extremely unusual, and consideration should be given to repeat confirmatory testing.
Principles in action
Safe and quality care
This recommendation was adapted from the CCO 2014 guidelines on systemic therapy (Canada). The source recommendation was based on a systematic review of the evidence conducted to March 2012 and was not graded by the source guideline authors. The source recommendation was adapted by making it more directive, replacing 'consensus was not reached' with 'consider' but noting that tumours of this type are rare. The repeat confirmatory testing can be repeat ER testing or repeat ER and PR testing on a different block if available.